HPLC-UV Analysis of Phloretin in Biological Fluids and Application to Pre-Clinical Pharmacokinetic Studies
نویسندگان
چکیده
Phloretin [3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan1-one] is a hydrophobic, dihydrochalcone, polyphenolic compound (MW 274.3 g/mol, XlogP 2.6) that has been identified in apples and other natural sources including Pieris japonica, Kalmia latifolia, Hoveniae Lignum, and Loiseleuria procumbens [1-6] (Figure 1). Phloridzin is the glycoside of phloretin (phloretin-2’-glucose) which has been identified in apples, strawberries, and several other plants
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